pathway -log10(p-value) genes KEGG_CELL_CYCLE 20.52 CDK4,TGFB2,E2F1,E2F3,E2F2,CCNE1,CCNE2,CCND2,PCNA,CDK1,CCNB1,SKP2,CCNB2,BUB1,CDC20,MAD2L1,PKMYT1,MCM4,MCM6,MCM7,MCM2,CCNA2,CHEK1,CDC25A,ESPL1,CHEK2,CDC7,CDC45,DBF4,CDC14A,ORC6,CDC6,BUB1B,TTK,ORC1 KEGG_PATHWAYS_IN_CANCER 8.63 PIK3R1,MAPK10,IL6,CDK4,TGFB2,MET,E2F1,E2F3,E2F2,ITGA2,TGFBR2,FIGF,FOS,CCNE1,CCNE2,FGFR2,FGF2,FGF14,COL4A4,SKP2,FZD4,FZD3,SLC2A1,MMP1,RAD51,MITF,EGLN3,BIRC5,TRAF4,ZBTB16,DAPK2,EPAS1,CKS1B KEGG_PI3K-AKT_SIGNLING_PATHWAY 7.57 PIK3R1,IL6,CDK4,MET,ITGA2,FIGF,CCNE1,CCNE2,FGFR2,CCND2,FGF2,FGF14,COL4A4,IL7R,THBS2,FLT4,COL11A1,COL6A3,COL5A2,COL1A1,TNXB,COL6A6,NR4A1,GNG7,GNG4,BRCA1,EFNA4,EFNA3,ANGPT1,TEK,COL4A3,COL6A5 KEGG_AXON_GUIDANCE 6.81 MET,NFATC4,NFATC1,CXCL12,LIMK1,EFNA4,EFNA3,ABLIM3,SLIT2,ROBO2,SEMA3G,SEMA6D,SEMA6A,SLIT3,SEMA5A,EFNB2,DPYSL2,NTN4 KEGG_CELL_ADHESION_MOLECULES_CAMS 6.59 HLA-DOA,ITGAL,JAM3,JAM2,CLDN18,CDH5,CD34,CDH2,ESAM,PTPRM,CADM3,SIGLEC1,SELP,SPN,VCAN,NFASC,CNTNAP2,NEGR1 KEGG_P53_SIGNALING_PATHWAY 5.61 CDK4,CCNE1,CCNE2,CCND2,CDK1,RRM2,CCNB1,CCNB2,CHEK1,CHEK2,GTSE1,SESN1 KEGG_DNA_REPLICATION 5.46 POLE,PCNA,RFC4,MCM4,MCM6,MCM7,MCM2,FEN1,DNA2 KEGG_ECM_RECEPTOR_INTERACTION 4.83 ITGA2,COL4A4,CD36,THBS2,COL11A1,COL6A3,COL5A2,COL1A1,TNXB,COL6A6,SV2A,HMMR KEGG_SMALL_CELL_LUNG_CANCER 4.83 PIK3R1,CDK4,E2F1,E2F3,E2F2,ITGA2,CCNE1,CCNE2,COL4A4,SKP2,TRAF4,CKS1B KEGG_PANCREATIC_CANCER 4.82 PIK3R1,MAPK10,CDK4,TGFB2,E2F1,E2F3,E2F2,TGFBR2,FIGF,RAD51,ARHGEF6 KEGG_FOCAL_ADHESION 4.36 PIK3R1,MAPK10,MET,ITGA2,FIGF,CCND2,COL4A4,MYLK,THBS2,FLT4,COL11A1,COL6A3,COL5A2,COL1A1,TNXB,COL6A6,RASGRF1,CAV1 KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION 4.09 PIK3R1,MAPK10,ADCY9,CDK1,CCNB1,CCNB2,BUB1,MAD2L1,PKMYT1,CCNA2,CDC25A KEGG_ABC_TRANSPORTERS 4.05 CFTR,ABCA6,ABCA3,ABCC3,ABCC9,ABCG2,ABCA8,ABCA4 KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 3.79 IL6,TGFB2,MET,TGFBR2,FIGF,CXCL12,IL7R,FLT4,CXCL9,CXCL2,CCL14,CCL19,CX3CL1,CX3CR1,ACVRL1,CXCL16,BMPR2,CD27,PLEKHO2,IL18R1 KEGG_OOCYTE_MEIOSIS 3.67 ADCY9,CCNE1,CCNE2,CDK1,CCNB1,CCNB2,BUB1,CDC20,MAD2L1,PKMYT1,ESPL1,AURKA KEGG_MELANOMA 3.42 PIK3R1,CDK4,MET,E2F1,E2F3,E2F2,FGF2,FGF14,MITF KEGG_BLADDER_CANCER 3.4 CDK4,E2F1,E2F3,E2F2,FIGF,MMP1,DAPK2 KEGG_HIF1_SIGNLING_PATHWAY 3.37 PIK3R1,IL6,LDHA,SLC2A1,TFRC,EGLN3,CYBB,EDN1,ANGPT1,TEK,HKDC1 KEGG_WNT_SIGNALING_PATHWAY 3.16 MAPK10,NFATC4,CCND2,NFATC1,FZD4,FZD3,SFRP2,PRICKLE1,DKK2,WIF1,PRICKLE2,DKK1,SFRP4 KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 3.01 PIK3R1,CXCL12,ITGAL,JAM3,JAM2,CLDN18,CDH5,ESAM,NCF2,CYBB,RAPGEF4 KEGG_RENAL_CELL_CARCINOMA 2.83 PIK3R1,TGFB2,MET,FIGF,SLC2A1,GAB1,EGLN3,EPAS1 KEGG_CHEMOKINE_SIGNALING_PATHWAY 2.75 PIK3R1,ADCY9,CXCL12,CXCL9,CXCL2,CCL14,CCL19,CX3CL1,CX3CR1,CXCL16,GNG7,GNG4,GRK5,PREX1 KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM 2.35 IL6,TGFB2,ITGA2,CACNA2D2,DMD,SGCD,SGCA,ACE KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 2.18 PIK3R1,ITGA2,FGFR2,PIP5K1B,FGF2,FGF14,ITGAL,MYLK,LIMK1,ARHGEF6,PFN2,IQGAP3,RDX,NCKAP1L KEGG_DILATED_CARDIOMYOPATHY 2.17 ADCY9,TGFB2,ITGA2,ADRB1,CACNA2D2,DMD,SGCD,SGCA KEGG_CHRONIC_MYELOID_LEUKEMIA 2.16 PIK3R1,CDK4,TGFB2,E2F1,E2F3,E2F2,TGFBR2 KEGG_VIRAL_MYOCARDITIS 2.16 HLA-DOA,ITGAL,DMD,SGCD,SGCA,MYH11,CAV1 KEGG_TIGHT_JUNCTION 2.15 CDK4,PRKCE,JAM3,JAM2,MYH11,CLDN18,MAGI1,MAGI3,AMOTL1,EPB41L2 KEGG_TRYPTOPHAN_METABOLISM 2.09 ALDH2,MAOB,CAT,KMO,INMT KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 2.08 ITGA2,CACNA2D2,DMD,SGCD,SGCA,CDH2,PKP2 KEGG_MAPK_SIGNALING_PATHWAY 2.05 MAPK10,TGFB2,TGFBR2,NFATC4,FOS,FGFR2,FGF2,FGF14,CACNA2D2,MAP3K3,RASGRF1,NR4A1,NTRK2,STMN1,DUSP1,MAPK8IP3 KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 2.02 ADRB1,ADRB2,EDNRB,PTAFR,CALCRL,PTGIR,AGTR2,PTGER4,THRB,SSTR1,APLNR,TRPV1,GABRE,CNR1,VIPR1,CHRNA5 KEGG_COLORECTAL_CANCER 1.94 PIK3R1,MAPK10,TGFB2,TGFBR2,FOS,BIRC5 KEGG_HEMATOPOIETIC_CELL_LINEAGE 1.77 IL6,ITGA2,CD36,IL7R,TFRC,CD34,CD37 KEGG_RENIN_ANGIOTENSIN_SYSTEM 1.76 AGTR2,ACE,NLN KEGG_PROSTATE_CANCER 1.75 PIK3R1,E2F1,E2F3,E2F2,CCNE1,CCNE2,FGFR2 KEGG_PPAR_SIGNALING_PATHWAY 1.74 CD36,SORBS1,MMP1,ACADL,SCD5,OLR1 KEGG_LEISHMANIA_INFECTION 1.67 TGFB2,HLA-DOA,FOS,FCGR3A,MARCKSL1,NCF2 KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 1.66 ADCY9,GNAQ,PRKCE,MYLK,MYH11,NPR1,CALCRL,PTGIR KEGG_BASE_EXCISION_REPAIR 1.64 POLE,PCNA,FEN1,SMUG1 KEGG_ENDOCYTOSIS 1.62 MET,FGFR2,PIP5K1B,ADRB1,ADRB2,NEDD4L,TFRC,GRK5,ARAP2,DAB2,EHD2 KEGG_NON_SMALL_CELL_LUNG_CANCER 1.62 PIK3R1,CDK4,E2F1,E2F3,E2F2 KEGG_ADHERENS_JUNCTION 1.59 MET,TGFBR2,SORBS1,PTPRM,PTPRB,LMO7 KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 1.58 PIK3R1,PIP5K1B,PRKCE,FCGR3A,LIMK1,MARCKSL1,PLA2G4F KEGG_PURINE_METABOLISM 1.55 ADCY9,POLE,RRM2,HPRT1,NPR1,PPAT,AK4,PDE5A,PDE2A,PAICS KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT 1.54 VAMP2,STX12,STX1A,STX11 KEGG_MELANOGENESIS 1.49 ADCY9,GNAQ,FZD4,FZD3,EDNRB,MITF,EDN1 KEGG_MISMATCH_REPAIR 1.46 PCNA,RFC4,EXO1 KEGG_GLYCOLYSIS_GLUCONEOGENESIS 1.41 ALDH2,ADH1B,LDHA,GPI,TPI1 KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION 1.35 ADCY9,VAMP2,AQP4,DYNC2H1 KEGG_GLIOMA 1.34 PIK3R1,CDK4,E2F1,E2F3,E2F2 KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY 1.3 MAPK10,SOCS3,ACACB,CD36,SLC2A1 KEGG_GAP_JUNCTION 1.29 ADCY9,ADRB1,GNAQ,CDK1,TUBB3,TUBB2B KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION 1.28 MAPK10,MET,JAM3,JAM2,HBEGF KEGG_TYPE_II_DIABETES_MELLITUS 1.27 PIK3R1,MAPK10,SOCS3,PRKCE KEGG_HOMOLOGOUS_RECOMBINATION 1.26 RAD51,RAD54L,RAD54B KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM 1.14 PPAT,CAD,ASNS KEGG_PROPANOATE_METABOLISM 1.11 ALDH2,LDHA,ACACB KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE 1.1 B4GALT3,CHST6 KEGG_CYSTEINE_AND_METHIONINE_METABOLISM 1.08 LDHA,DNMT3A,DNMT3B KEGG_PHENYLALANINE_METABOLISM 0.97 MAOB,AOC3 KEGG_TGF_BETA_SIGNALING_PATHWAY 0.96 TGFB2,TGFBR2,THBS2,ACVRL1,BMPR2 KEGG_PYRUVATE_METABOLISM 0.93 ALDH2,LDHA,ACACB KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0.9 SOCS3,SKP2,CDC20,NEDD4L,BRCA1,UBE2S,UBE2C KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY 0.89 PIK3R1,MAPK10,IL6,FOS,CXCL9,TLR8 KEGG_FATTY_ACID_METABOLISM 0.89 ALDH2,ADH1B,ACADL KEGG_TYROSINE_METABOLISM 0.89 MAOB,ADH1B,AOC3 KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION 0.89 PIK3R1,NEDD4L,NR3C2 KEGG_NUCLEOTIDE_EXCISION_REPAIR 0.85 POLE,PCNA,RFC4 KEGG_COMPLEMENT_AND_COAGULATION_CASCADES 0.84 C7,PLAU,F8,THBD KEGG_BETA_ALANINE_METABOLISM 0.84 ALDH2,AOC3 KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE 0.84 CHPF2,UST KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS 0.84 SCD5,ELOVL6 KEGG_NOTCH_SIGNALING_PATHWAY 0.79 NOTCH4,KAT2A,KAT2B KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION 0.77 IL6,HLA-DOA,CXCL12 KEGG_GLUTATHIONE_METABOLISM 0.74 RRM2,GPX3,GCLC KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 0.73 PIK3R1,MAPK10,MAP3K3,GAB1,NTRK2,SH2B3 KEGG_ARGININE_AND_PROLINE_METABOLISM 0.67 ALDH2,MAOB,PYCR1 KEGG_HISTIDINE_METABOLISM 0.67 ALDH2,MAOB KEGG_GNRH_SIGNALING_PATHWAY 0.65 MAPK10,ADCY9,GNAQ,MAP3K3,HBEGF KEGG_VIBRIO_CHOLERAE_INFECTION 0.65 ADCY9,CFTR,SEC61A2 KEGG_ASTHMA 0.65 HLA-DOA,MS4A2 KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM 0.63 MAOB,AOC3 KEGG_ARACHIDONIC_ACID_METABOLISM 0.62 GPX3,ALOX5,CYP2U1 KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 0.61 PIK3R1,CDK4,NFATC4,FOS,NFATC1 KEGG_BUTANOATE_METABOLISM 0.58 ALDH2,HMGCS1 KEGG_PRION_DISEASES 0.56 IL6,C7 KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY 0.54 PIK3R1,NFATC4,FOS,NFATC1 KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY 0.53 PIK3R1,MAPK10,PRKCE,MS4A2 KEGG_ERBB_SIGNALING_PATHWAY 0.49 PIK3R1,MAPK10,GAB1,HBEGF KEGG_GRAFT_VERSUS_HOST_DISEASE 0.46 IL6,HLA-DOA KEGG_CALCIUM_SIGNALING_PATHWAY 0.44 ADCY9,ADRB1,GNAQ,MYLK,ADRB2,EDNRB,PTAFR KEGG_PYRIMIDINE_METABOLISM 0.43 POLE,RRM2,CAD,TK1 KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION 0.43 ALDH2,HMGCS1 KEGG_LYSINE_DEGRADATION 0.43 ALDH2,SUV39H2 KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM 0.43 GPI,GNPNAT1 KEGG_TYPE_I_DIABETES_MELLITUS 0.43 HLA-DOA,HSPD1 KEGG_N_GLYCAN_BIOSYNTHESIS 0.41 B4GALT3,MGAT3 KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY 0.37 MAPK10,IL6,CXCL2 KEGG_DRUG_METABOLISM_CYTOCHROME_P450 0.33 MAOB,ADH1B,FMO2 KEGG_VEGF_SIGNALING_PATHWAY 0.31 PIK3R1,NFATC4,NFATC1 KEGG_PARKINSONS_DISEASE 0.23 UCHL1,LRRK2 KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 0.22 PIK3R1,NFATC4,NFATC1,ITGAL,FCGR3A KEGG_INSULIN_SIGNALING_PATHWAY 0.22 PIK3R1,MAPK10,SOCS3,ACACB,SORBS1 KEGG_STARCH_AND_SUCROSE_METABOLISM 0.18 GPI,PGM2L1 KEGG_GLYCEROLIPID_METABOLISM 0.18 ALDH2,AGPAT4 KEGG_DRUG_METABOLISM_OTHER_ENZYMES 0.18 HPRT1,TK1 KEGG_MTOR_SIGNALING_PATHWAY 0.18 PIK3R1,FIGF KEGG_STEROID_HORMONE_BIOSYNTHESIS 0.17 AKR1C2,HSD17B6 KEGG_INOSITOL_PHOSPHATE_METABOLISM 0.17 PIP5K1B,TPI1 KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY 0.17 IL6,IL33 KEGG_BASAL_CELL_CARCINOMA 0.17 FZD4,FZD3 KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION 0.16 TUBB3,TUBB2B KEGG_ACUTE_MYELOID_LEUKEMIA 0.16 PIK3R1,ZBTB16 KEGG_JAK_STAT_SIGNALING_PATHWAY 0.09 PIK3R1,IL6,CCND2,SOCS3,IL7R KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS 0 HLA-DOA,FCGR3A,C7,H2AFX KEGG_LYSOSOME 0 LAMP3,LAPTM4B,ACP5 KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 0 ADH1B,AKR1C2 KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM 0 PIK3R1,PIP5K1B